The Role of Glutathione-S Transferase in Psoriasis and Associated Comorbidities and the Effect of Dimethyl Fumarate in This Pathway

The Role of Glutathione-S Transferase in Psoriasis and Associated Comorbidities and the Effect of Dimethyl Fumarate in This Pathway

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Psoriasis vulgaris is a chronic inflammatory skin disease characterized by well-demarcated click here scaly plaques.Oxidative stress plays a crucial role in the psoriasis pathogenesis and is associated with the disease severity.Dimethyl fumarate modulates the activity of the pro-inflammatory transcription factors.

This is responsible for the downregulation of inflammatory cytokines and an overall shift from a pro-inflammatory to an anti-inflammatory/regulatory response.Both steps are necessary for the amelioration of psoriatic inflammation, although additional mechanisms have been proposed.Several studies reported a long-term effectiveness and safety of dimethyl fumarate monotherapy in patients with moderate-to-severe psoriasis.

Furthermore, psoriasis is a chronic disease often associated to metabolic comorbidities, as obesity, diabetes, and cardiovascular diseases, in which glutathione-S transferase deregulation is present.Glutathione-S transferase is involved in the antioxidant system.An increase of its activity in psoriatic epidermis in comparison with the uninvolved and normal epidermal biopsies has been reported.

Dimethyl fumarate depletes glutathione-S transferase by formation of covalently linked conjugates.This review investigates the anti-inflammatory role of dimethyl fumarate in oxidative stress laguna 3hp dust collector and its effect by reducing oxidative stress.The glutathione-S transferase regulation is helpful in treating psoriasis, with an anti-inflammatory effect on the keratinocytes hyperproliferation, and in modulation of metabolic comorbidities.